Hereditary neuropathy with pressure palsies (HNPP)
HNPPranges in severity some people get no symptoms at all or find it a minor nuisance, while others are so badly affected they can't even move the affected limb.
Most people with HNPP have attacks of numbness, tingling and muscle weakness in:
These symptoms happen because the layer of proteincovering and protectingthe nerve(the myelin sheath) is faulty. For more information, see What's the cause?
Some episodes last just a few minutes, while others can last months.
Symptomscan betriggered by simple actions, usually:
HNPP is not life-threatening.How severe it is and the way it progresses can differ greatly from person to person.
Symptoms usually start in theteenage years or 20s-30s, although they can sometimes develop later in life or in childhood.
Some people start off with mild symptoms, or episodes in one particular area that come and go.
About half of peoplewith HNPP fully recover after experiencing symptoms, never to have another episode, as the nerves have rebuilt their protective covering.
But the nerves don't completely recover for everyone with HNPP. For some people, the nerve only partially heals after being damaged, and they are left with recurrent or permanent nerve symptoms and muscle problems. However, these symptoms are usually mild, and it's unusual to be left with asevere disability.
Hereditary neuropathy with pressure palsies (HNPP) is an inherited nerve disorder that typically causes numbness, tingling and muscle weakness.
HNPPranges in severity some people get no symptoms at all or find it a minor nuisance, while others are so badly affected they can't even move the affected limb. Most people with HNPP have attacks o
We needtwo PMP22 genes, one from each parent, for the normal development of the peripheral nerves.These genesprovide instructions for the creation of PMP22 protein, whichmakes uptheprotective outer la
A diagnosis of HNPP is based on symptoms(such asrecurrent loss of sensation in one particular area), evidence of a family history and electrical nerve tests. A genetic test will confirm the diagnosis.
There's currently no cure for HNPP, but some of the symptoms can be treated, and lifestyle changes can make a huge difference. Lifestyle advice Ifyou can feel anywarning signs (such as tingling),sto
HNPP.org HNPP UK Hereditary Neuropathy Foundation CMT UK