Symptoms of systemic lupus erythematosus (SLE) can vary widely from person to person. Some people may only experience a few mild symptoms, whereas others may be more severely affected.

Even if you usually have mild symptoms, SLE can "flare up", with symptoms becoming more severe or new symptoms developing.

The three main symptoms of SLE are:

  • fatigue (extreme tiredness)
  • Joint pain and swelling
  • rashes particularly on the face, wrists and hands


Fatigue is one of the most common symptoms of SLE. You may feel very tired even though youget plenty of sleep. Carrying out everyday tasks, such as housework or office work, can leave you feeling exhausted.

Many people with SLE find that fatigue is the most distressing and disruptive aspect ofthe conditionbecause it has a negative impact ontheir work and social life.

Joint pain

If you have SLE, you're likely to experience joint pain in your hands and feet. You may find the pain changes from one set of joints to another quite quickly, and is usually worse in the morning.

Unlike some other conditions that affect the joints, SLE is unlikely to cause your joints to become permanently damaged or deformed.


Many people with SLE develop rashes on their skin most commonly on the face, wrists and hands. A rash over the cheeks and the bridge of the nose is particularly common and is known as a "butterfly rash" or "malar rash".

Rashes caused by SLE mayget betterafter a few days or weeks, but can last longer or even be permanent.

Rashes caused by SLE can sometimes be itchy or painful. They may get worse if they are exposed to sunlight.

Other symptoms

SLE can also cause a wide range of other symptoms.However, you're unlikelyto have all of the symptoms listed below, and many people with the condition only experiencethe above main symptoms.

Otherfeatures of SLE may include:

  • a fever (high temperature)
  • swollen lymph glands (small glands found throughout your body, including in your neck, armpits and groin)
  • recurring mouth ulcers
  • hair loss (alopecia)
  • high blood pressure (hypertension)
  • headaches and migraines
  • stomach (abdominal) pain
  • chest pain
  • depression
  • dry eyes
  • memory loss
  • seizures (fits)
  • problems thinking clearly and difficulty telling the difference between reality and imagination ( psychosis )
  • shortness of breath
  • Raynaud's phenomenon a condition that limits the blood supply to your hands and feetwhen it is cold
  • ankle swelling and fluid retention ( oedema )

When to seek medical advice

You should see your GP if you have persistent or troublesome symptoms that you think could be caused by SLE.

While it is likely that your symptoms are being caused by a more common condition, it's important to see a doctor for a diagnosis.


Content supplied by the NHS Website

Medically Reviewed by a doctor on 28 Sep 2016