Causes of nephrotic syndrome

Most children with nephrotic syndrome have "minimal change disease". This means thattheir kidneys appear normal or nearly normal if a tissue sampleis studied under a microscope. The cause of minimal change disease is unknown.

Nephrotic syndrome can sometimesoccur as a result of a kidney problem or another condition, such as:

  • glomerulosclerosis when the inside of the kidney becomes scarred
  • glomerulonephritis inflammation inside the kidney
  • an infection such as HIV or hepatitis
  • lupus
  • diabetes
  • sickle cell anaemia
  • in very rare cases, certain types of cancer such as leukaemia , multiple myeloma or lymphoma

These problems tend to be more common in adults with nephrotic syndrome.

Content supplied by the NHS Website

Medically Reviewed by a doctor on 21 Dec 2018